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KMID : 1098420230310020107
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Korean Journal of Medicinal Crop Science
2023 Volume.31 No. 2 p.107 ~ p.115
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Immunosuppressive Effects of Amomum muricarpum Elmer in Lipopolysaccharide-triggered Inflammatory Signaling Pathway
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Park Yong-Gun
Kim Seon-Sook
Seo Su-Ryeon
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Abstract
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Background : Identifying new natural products to controlling inflammatory responses involved in screening of Asian native plants. The screening revealed a potential candidate, Amomum muricarpum Elmer, which is a traditional medicinal plant for gastrointestinal diseases in Vietnam; however, its scientific basis remains unknown, its scientific basis remain unknown.
Methods and Results : A. muricarpum extract suppressed lipopolysaccharide (LPS)-induced the protein expression of inflammatory mediators such as interleukine (IL)-1β and cyclooxygenase-2 in mouse-derived RAW264.7 macrophages. The mRNA expression levels of IL-6, IL-1β, tumor necrosis factor-α, and inducible nitric oxide synthase in response to LPS were reduced by A. muricarpum extract. Additionally, A. muricarpum extract inhibited phosphorylation of the signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB). This result indicates A. muricarpum suppressed the expression of inflammatory cytokines and mediators by inhibiting signal transducer and STAT3 and NF-κB activation.
Conclusions : This is the first scientific evidence to report that A. muricarpum suppresses inflammatory signaling pathways and can potentially manage excessive and chronic inflammatory responses.
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KEYWORD
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Amomum muricarpum Elmer, Inflammation, Lipopolysaccharide, Nuclear Factor Kappa B, Signal Transducer and Activator of Transcription 3
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